Growing evidence from multimodal brain-imaging studies highlights the importance of a synergistic approach toward characterizing the neurobiological substrate of reading disability (RD). The overall goal of this project is to develop a comprehensive neurobiological model of text comprehension that will supplement the cognitive framework developed within the Executive Functions project. In addition, we propose to evaluate features of brain organization associated with developmental outcomes of educational interventions addressed in our Intervention project.
This project will address the following three aims:
We will characterize features of brain organization that support sentence comprehension, using a multiple-task and multimodal imaging approach (fMRI, quantitative structural MRI, and DTI) to identify neural components of reading comprehension that are print dependent (associated with sentence reading and word recognition) and print independent (associated with executive functions) in nonimpaired readers and in students experiencing text comprehension difficulties.
We will examine the predictive value of preintervention multimodal imaging data for subsequent response to intervention. We will model individual response to educational interventions (provided in the current Intervention project) as a function of aberrant features of (a) the brain organization for comprehension in RD, (b) imaging sentence reading and response inhibition, and (c) functional connectivity.
We will investigate functional changes in brain organization after educational interventions by focusing on adequate and inadequate responders in conjunction with the current Classification and Integration project, using data collected for aims 1 and 2. We will evaluate alternative models of functional brain plasticity in association with successful response to intervention (i.e., “normalization” vs. “compensation”).
By successfully addressing these aims, this project will promote novel directions in cognitive neuroscience research that features combinations of several multimodal imaging methods to identify features of brain organization that are crucial for typical development of reading comprehension skills and successful intervention outcomes.
Although much attention has been devoted to neural processes underlying word reading, less is known about the neural correlates of reading comprehension, especially in relation to instructional response and executive functions. Multimodal imaging promises a more comprehensive understanding of the brain mechanisms associated with adequate and inadequate instructional response and the neural correlates of reading comprehension in typically developing and struggling readers.
Elementary and middle schools in the Houston and Austin areas
Williams, V. J., Juranek, J., Cirino, P. T., & Fletcher, J. M. (2017). Cortical thickness and local gyrification in children with developmental dyslexia. Cerebral Cortex. doi:10.1093/cercor/bhx001
Dimitriadis, S. I., Laskaris, N. A., Simos, P. G., Fletcher, J. M., & Papanicolaou, A. C. (2016). Greater repertoire and temporal variability of cross-frequency coupling (CFC) modes in resting-state neuromagnetic recordings among children with reading difficulties. Frontiers in Human Neuroscience, 10. doi:10.3389/fnhum.2016.00163
Sideridis, G.D., Simos, P., Papanicolaou, A.C., Fletcher, J.M. (2014). Using covariance structure modeling to assess functional connectivity in the brain: Power and sample size considerations. Educational and Psychological Measurement, 74, 733-758. PMCID: PMC4245025
Fletcher, J.M. (2013, December). Enhancing Reading Outcomes: RTI and the Brain. Presentation made at the Cincinnati Children's Hospital.
Fernandez, V.G., Juranek, J.J., Stuebing, K.K., & Fletcher, J.M. (2013). Volumetric analysis of regional variability in the cerebellum of children with dyslexia. Cerebellum, 12, 906–915. NIHMS: 543303 PMID:23828023
Dimitriadis, S.I., Laskaris, N.A., Simos, P.G., Micheloyannis, S., Fletcher, J.M.,Rezaie, R. & Papanicolaou, A.C. (in press). Altered temporal correlations in resting-state connectivity fluctuations in children with reading difficulties detected via MEG. NeuroImage, 83, 307-317. PMCID: PMC23777755
Rezaie, R., Simos, P.G., Fletcher, J.M., Denton, C., and Papanicolaou, A.C. (2012). Exploring the brain mechanism for typical and impaired reading ability using magnetic source imaging. In Z. Breznitz, V. Berninger, and O. Rubinsten (Eds.). Listening to many voices: Reading, writing, math and the brain. Springfield IL: Springer.
Fletcher, J.M., Molfese, D.L., Simos, P.G., Papanicolaou, A.C., & Denton, C.A. (2010). Neuroimaging. In N. Duke and A. Mallette (Eds.). Literacy methodologies (2nd ed.). New York: Guilford.
Denton, C.A., Fletcher, J.M., Simos, P.G., Papanicolaou, A.C., & Anthony, J. L. (2007). An implementation of a tiered intervention model: Reading outcomes and neural correlates. In D. Haager, S. Vaughn, & J.K. Klingner (Eds.), Validated reading practices for three tiers of intervention (pp. 107-137). Baltimore, Maryland: Paul H. Brookes.
Simos, P.G., Rezaie, R., Fletcher, J.M., & Papanicolaou, A.C. (2013). Time constrained functional connectivity analysis of cortical networks underlying phonological decoding in typically developing school-aged children: A magnetoencephalography study. Brain and Language, 125 (2), 156-164. NIHMS: 397858 PMCID: 3505242
Molfese, P.J.,& Fletcher, J.M. (in press). Adequate versus inadequate response to reading intervention. An event-related potentials assessment. Brain and Language. NIHMS: 543307
Rezaie, R., Simos, P., Fletcher, J., Cirino, P., Vaughn, S., & Papanicolaou, A. C. (2011). Engagement of temporal lobe regions predicts response to educational interventions in adolescent struggling readers. Developmental Neuropsychology, 36(7), 869-888. PMCID: PMC21978010
Vourkas, M., Micheloyannis, S, Simos, P.G., Rezaie, R. Fletcher, J.M., & Papanicolaou, A.C. (2011). Dynamic task-specific brain network connectivity in children with severe reading difficulties. Neuroscience Letters, 488, 123-128. PMCID: PMC3014432
Simos, P.G., Rezaie, R., Fletcher, J.M., Juranek, J.J., & Papanicolaou, A.C. (2011). Neural correlates of sentence reading in children with reading difficulties. NeuroReport, 22(14), 674-678. PMCID: PMC3164957
Simos, P., Rezaie, R., Fletcher, J., Juranek, J., Passaro, A., & Papanicolaou, A.C. (2011). Functional disruption of the brain mechanism for reading: Effects of comorbidity and task difficulty among children with developmental learning problems. Neuropsychology, 24, 520-534. PMCID: PMC3192455
Rezaie, R., Simos, P.G., Fletcher, J.M., Juranek, J. Cirino, P.T., Li, Z., Passaro, A.D., & Papanicolaou, A.C. (2011). The timing and strength of regional brain activation associated with word recognition in children with reading difficulties. Frontiers in Human Neuroscience, 5 (41), 1-12. PMCID: PMC3098420
Rezaie, R., Simos, P., Fletcher, J., Cirino, P., Vaughn, S., & Papanicolaou, A. C. (2011). Temporo-parietal brain activity as a longitudinal predictor of response to educational interventions among middle school struggling readers. Journal of the International Neuropsychological Society, 17, 875 - 885. PMCID: PMC3174865
Passaro, A.D., Rezaie, R., Moser, D., Li, Z., Dias, N., & Papanicolaou, A.C. (2011). Optimizing estimation of hemispheric dominance for language using Magnetic Source Imaging. Brain Research, 1416, 44-50. (Project 4). PMCID: PMC21890118
Simos, P.G., Pugh, K., Mencl, E., Frost, S., Fletcher, J.M., Sarkari, S., & Papanicolaou, A.C. (2009). Temporal course of word recognition in skilled readers: A magnetoencephalography study. Behavioral Brain Research, 197, 45-54. PMCID: PMC2630285
Fletcher, J. M., & Vaughn, S. (2009). RTI models as alternatives to traditional views of learning disabilities: Response to the commentaries. Child Development Perspectives, 3(1), 48-50. PMCID: PMC3032407